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ManausWilson Duarte Alecrim Maria das Graças Alecrim Malaria Research in the Amazonas State FMT-AM CuiabáCor Jesus Fernandes Fontes Francisco Jose Dutra.

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Apresentação em tema: "ManausWilson Duarte Alecrim Maria das Graças Alecrim Malaria Research in the Amazonas State FMT-AM CuiabáCor Jesus Fernandes Fontes Francisco Jose Dutra."— Transcrição da apresentação:

1 ManausWilson Duarte Alecrim Maria das Graças Alecrim Malaria Research in the Amazonas State FMT-AM CuiabáCor Jesus Fernandes Fontes Francisco Jose Dutra Souto Nucleus of Infectious and Tropical Diseases in Mato Grosso –UFMT BrasíliaPedro Luiz Tauil João Barberino Santos Elisabeth Carmen Duarte Nucleus of Tropical Medicine-UFB Belo-HorizonteAntoniona U. KrettliExperimental and Human Malaria FIOCRUZ Luzia Helena Carvalho Luciano Andrade Moreira Malaria Molecular Biology and Immunology – FIOCRUZ Rio de JaneiroJosé Daniel Figueroa-Villar Luzineide Wanderley Tinoco Synthesis, Spectroscopy, Molecular Modeling and Biological Evaluation of Bioactive Compounds –IME Claudio T. Daniel Ribeiro Leonardo Carvalho Maria F. Ferreira da Cruz Centre for Malaria Research and Training FIOCRUZ Mariano Gustavo ZalisMalaria Molecular Biology –UFRJ Solange Wardell Isabela Ribeiro FIOCRUZ/Farmanguinhos DNDi - WHO São PauloHernando A. del Portillo Obando Maria Del Carmen F. Becerra Molecular Biology of Plasmodium-USP Alejandro Miguel KatzinMalaria Drug Resistance –USP

2 New Drugs Synthesis and Natural Products

3 Antoniana Krettli et al. Antimalarial activity of 4-(5-trifluoromethyl-1H-pyrazol-1- yl)-chloroquine analogues

4 Traditional medicine in Brazil, antimalarial tests and opportunities for malaria control Antoniana Ursine KRETTLI & M.Graça Lins BRANDÃO Ampelozyziphus amazonicus, the Indian beer Bidens pilosa, called picão,

5

6 Figueroa-Villar et al. Synthesis of Derivatives of the 2,4,6- triaminopirimidinas ()

7 Introduction of new drug regimens Solange Wardell and coworkers and Isabela Ribeiro Development of an artesunate / mefloquine co- formulation The results of the 500-patient clinical study comparing AS/MQ with existing separate tablet formulations show a very high cure rate for patients in both groups – 94.1% for AS/MQ and 92.0% for the separate tablet formulation.

8 Assessment of philosseptin-1, a peptide isolated from the cutaneous secretion of Phyllomedusa hypochondrialis activity, and its activity on the P. falciparum growth. Carlos Eduardo Tosta

9 Cor Jesus Fernandes Fontes Proguanil plus sulfamethoxazole in the treatment of uncomplicated Plasmodium falciparum malaria proguanil 100 mg BID plus sulfamethoxazole 1000 mg BID for 7 days

10 Drug resistance in P. vivax and P. falciparum In vitro drug test methodologies for fresh field isolates. Molecular mechanisms of drug resistance

11 Evaluation of Plasmodium falciparum and P. vivax sensitivity to antimalarials using the DELI-TEST Carvalho LJM; Chehuan-Mello Y, Ferreira-da-Cruz MF, Druilhe P; Alecrim WD, Brasseur P, Daniel-Ribeiro CT. Distribution of IC50 (in nMol/ml) for the different drugs assayed for P. falciparum and P. vivax

12 to understand the basis of resistance of P. falciparum to antimalarial drugs (including artemisinin) and explore potentials to improve the potency of existing antimalarial drugs such as CQ, AQ and QN. Molecular determinants of drug response and resistance in P. falciparum of Africa and South America. Mariano Zalis

13 Transporters PF-A0590w, PFC0125w, PF , PF , PF , PF , PF , PFB0465c, PFL1125w PFL0620c PFE1185w, PF , PF , PFE0775c, PF , PF , PF , PFL1410c, PfATP6

14 In vitro sensitivity for Quinine amino acid position ISOLATEORIGIN PVL558Pt. Velho/BR MCP120 Macap á /BR MCP120 Macap á /BR RBR710Rondônia/BR BEL307 Bel é m/BR BEL351 Bel é m/BR MCP155 Macap á /BR RBR710Rondônia/BR PVL558Pt. Velho/BR MCP120 Macap á /BR MCP151 Macap á /BR MCP114 Macap á /BR MCP186 Macap á /BR MCP189 Macap á /BR MCP196 Macap á /BR MCP197 Macap á /BR MCP138 Macap á /BR MCP120 Macap á /BR MCP116 Macap á /BR MCP177 Macap á /BR MCP177 Macap á /BR MCP191 Macap á /BR SPO23B.Ventura/CO SOP42B.Ventura/CO SOP38B.Ventura/CO SOP19B.Ventura/CO Increase IC 50 values to quinine SNPs analysis of the PFA0590w gene and IC 50 values to quinine in South America mutation wild type -3D7 Brasil Colômbia IC 50 range (38 nM – 257 nM) Brazil: nM Colombia: (38 – 147 nM)

15 Modulation of chloroquine sensitivity in P. falciparum by over-expression of a P. vivax ortholog of the chloroquine resistance transporter gene, pfcrt Juliana M Sa, Marcio M Yamamoto, Carmen Fernandez-Becerra, Thomas E Wellems, Hernando A del Portillo


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