Supplementary Figure 8 Cell cycle genes a.b. c. d. e.f. p21 Cip1 expression 6h12h24h48h72h 0.0 0.5 1.5 2.0 2.5 SERT 1uM DEX 1uM SERT 1uM+ DEX 1uM n=3 fold.

Apresentação em tema: "Supplementary Figure 8 Cell cycle genes a.b. c. d. e.f. p21 Cip1 expression 6h12h24h48h72h 0.0 0.5 1.5 2.0 2.5 SERT 1uM DEX 1uM SERT 1uM+ DEX 1uM n=3 fold."— Transcrição da apresentação:

1 Supplementary Figure 8 Cell cycle genes a.b. c. d. e.f. p21 Cip1 expression 6h12h24h48h72h 0.0 0.5 1.5 2.0 2.5 SERT 1uM DEX 1uM SERT 1uM+ DEX 1uM n=3 fold change from ctrl CDK2 expression 6h12h24h48h72h 0.0 0.5 1.5 2.0 2.5 SERT 1uM DEX 1uM DEX 1uM+ SERT 1uM n=3 fold change from control p53 6h12h24h48h72h 0.0 0.5 1.5 2.0 2.5 3.0 SERT 1uM DEX 1uM SERT 1uM+ DEX 1uM n=3 fold change from control CCND1 6h12h24h48h72h 0.0 0.5 1.5 2.0 2.5 SERT 1uM DEX 1uM SERT 1uM+ DEX 1uM * n=3 time course fold change from ctrl HDM2 6h12h24h48h72h 0.0 0.5 1.5 2.0 2.5 SERT 1uM DEX 1uM SERT 1uM+ DEX 1uM * n=3 fold change from control CCNA2 6h12h24h48h72h 0.0 0.5 1.5 2.0 2.5 SERT 1uM DEX 1uM SERT 1uM+ DEX 1uM n=3 fold change from control

2 Stress and glucocorticoid-responsive genes g.h. i.j. FKBP5 6h12h24h48h72h 0 2 3 4 SERT 1uM DEX 1uM SERT 1uM+ DEX 1uM * * * * * * n=3 fold change from control SGK1 6h12h24h48h72h 0 2 3 4 SERT 1uM DEX 1uM SERT 1uM+ DEX 1uM * * n=3 fold change from control FOXO1 6h12h24h48h72h 0.0 0.5 1.5 2.0 2.5 SERT 1uM DEX 1uM SERT 1uM+ DEX 1uM * * * ** * ** * * n=3 fold change from control GADD45B 6h12h24h48h72h 0.0 0.5 1.5 2.0 2.5 SERT 1uM DEX 1uM SERT 1uM+ DEX 1uM ** * * n=3 fold change from control

3 Neurotrophic factors and 5-HTR related genes k.l. m. BDNF 6h12h24h48h72h 0.0 0.5 1.5 2.0 2.5 SERT 1uM DEX 1uM SERT 1uM+ DEX 1uM n=3 fold change from contol p11 6h12h24h48h72h 0.0 0.5 1.5 2.0 2.5 SERT 1uM DEX 1uM SERT 1uM+ DEX 1uM * * n=3 fold change from control beta-arrestin 2 6h12h24h48h72h 0.0 0.5 1.5 2.0 2.5 SERT 1uM DEX 1uM SERT 1uM+ DEX 1uM ** n=3 fold change from control