Associação de estratégias nutricionais e treinamento físico na prevenção do declínio cognitivo associado ao envelhecimento Profª. Drª. Danusa Dias Soares Universidade Federal de Minas Gerias - UFMG LAFISE- Laboratório de Fisiologia do Exercício

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Educação Física e Velhice Perfil da população idosa no Brasil

esporte.gov.br/diesporte 2010 a 2013

esporte.gov.br/diesporte 2010 a 2013

esporte.gov.br/diesporte 2010 a 2013

Flavanóis do Cacau

ECO²DIA Effects of Exercise and COcoa flavanols on COgnitive functions in Type 1 DIAbetes.

HUMAN STUDIES Acute MRI COCOA Study UZ Brussels, BELGIUM August / September 2015 ACUTE Exercise + Cocoa study, CHRU LILLE Winter – spring 2016 CHRONIC Exercise + COCOA Study, UZ Brussels / BLITS / BASIC FIT BELGIUM

Pro – inflammatory cytokines (Ellinger & Stehle; 2016; Selmi et al. 2006) Anti– inflammatory cytokines (Ellinger & Stehle; 2016; Selmi et al. 2006) Increase anti oxidant capacity and protect cells from ROS (Myburgh 2014, Allgrove et al. 2011; Davison et al. 2012; Fraga et al. 2005) Improve vascular function and vasoreactivity (Davison et al. 2008; Heiss et al. 2005; Flammer et al. 2012; Berry et al. 2010; Schroeter et al. 2006) Exercício associado ao flavanol do cacau

Acute or chronic intake of cocoa did not improve exercise performance or recovery (Allgrove et al. 2011, Davison et al. 2012; Patel et al. 2015; Peschek et al. 2014; Stellingwerf et al. 2014; Taub et al. 2013) Levels of oxidative stress (F2 isoprostane, oxidized LDL’s, MDA) were reduced by the acute or sub- chronic (14days) intake of CF. (Allgrove et al. 2011, Davison et al. 2012; Sign et al. 2006; Fraga et al. 2005) Increase in DBP after exercise was tempered in obese people. FMD was increased after acute and chronic intake of Cocoa Flavanols. (Berry et al. 2010; Patel et al. 2015; Sign et al. 2006) Cocoa flavanol intake increased FFA during exercise, but had no effect on glucose, insulin, glucagon and cortisol levels. (Allgrove et al. 2011, Davison et al. 2008; Stellingwerf et al. 2014)

Flavanóis do Cacau e Exercício Inhibition of L- Arginase Inhibition of NADPH oxidase ↑anti oxidant defences ↓ cytokine production ↑NO production ↓NO inactivation ↑NO bio availability ↓anion superoxide (indirectly reflected by a decrease in markers of oxidative stress damage) ↓oxidative stress & inflammation ↑Mitochondrial Function ↑FMD (endothelial function) ↑Exercise-induced increased vasoreactivity ? Improve acute exercise recovery ?

Sokolov et al, 2013

40 ANOS DO LAFISE em 2016